CBFB and acute myeloid leukemia: The five most common chromosomal translocations in patients with AML are t(8;21), t(15;17), inv(16), der(11), and t(9;22), which encode the fusion genes RUNX1-RUNXT1 (AML1-ETO), PML-RARA, CBFB-MYH11, MLL-fusions, and BCR-ABL1, respectively (5).