Moreover, the study showed that in the same samples from newborns, the RNA profile changes induced by overweight mothers and obesity were also associated to alteration in PPAR-γ gene expression, a master regulator of adipogenesis and altered cytokine pro-inflammatory levels in vitro blood mononuclear cell response to metabolic stimuli (142). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.