As claimed by Bai S et al, MMP-2 is related to the progression of chronic diabetes complications, and exosomal circ_DLGAP4 regulates the expression of miR-143 and targets the ERBB3/NF-κB/MMP-2 axis, which triggers the occurrence of diabetic nephropathy (27). The gene discussed is ERBB3; the disease is diabetic kidney disease.