IGHE and allergic disease: Our previous study found that supplementation with the probiotic strain TMC3115 from birth to weaning can reduce the risk of the host suffering from IgE-mediated allergic diseases in adulthood, by regulating the composition of the gut microbiota, increasing short chain fatty acid (SCFA) production, and promoting the immune system and intestinal tissue development of the host (Cheng et al., 2019).