FFAR2 and obesity due to melanocortin 4 receptor deficiency: further found that maternally derived SCFA produced by a high dietary fiber diet during pregnancy can regulate the development of the intestinal tract and islets of the offspring during the embryonic period, through the maternal gut microbe-SCFA-embryo GPR41/GPR43 axis, to protect the offspring from metabolic diseases such as obesity (Kimura et al., 2020).