RNAseq studies using human esophageal biopsy samples from healthy donors and EoE patients identified ALOX15, CCL26, CLC, and CPA3 as well as the long non-coding RNA BRAF-activated non-coding RNA (BANCR) as the most upregulated genes and ALOX15, CCL26, CLC, and CPA3 as strongly downregulated genes (77). This evidence concerns the gene CPA3 and eosinophilic esophagitis.