Thereby, we demonstrate that our HEWP sensitization and challenge protocol not only induces systemic and local immune responses seen in human EoE patients (e.g., a Th2 response, anti-OVA IgE, and esophageal eotaxin production), but also the micro- and macro-pathological changes associated with human EoE (e.g., esophageal eosinophilia on histologic exam, and white exudates and linear furrows on endoscopic exam). This evidence concerns the gene IGHE and eosinophilic esophagitis.