In contrast, keywords colored in yellow-green (e.g., apoptosis, aortic aneurysm, restenosis, extracellular matrix, vascular injury, microRNA, reactive oxygen species, oxidative stress, autophagy, aortic dissection, intracranial aneurysm, aging, runx2, endoplasmic reticulum stress, macrophage) indicated that these topics gained more attention in recent years. The gene discussed is RUNX2; the disease is aortic aneurysm.