PFKFB3 and pulmonary fibrosis: An allosteric activator of phosphofructokinase-1, 6-phosphofructo-2-kinase/fructose-2,6- biphosphatase 3 (PFKFB3) is also upregulated in Transforming growth factor-β (TGF-β)-induced myofibroblasts, and the inhibition of PFKFB3 effectively decreases levels of myofibroblasts differentiation and pulmonary fibrosis (Xie et al., 2015).