The overloading of Ca2+ stimulated the binding with CaMKII to enhance the phosphorylation of CaMKII and CREB (Figure 3(b)), meanwhile, the levels of GRP78 and Caspase-12, ERS related proteins, were upregulated in HF mice (Figure 3(c)), suggesting that ERS can cause the degradation of SERCA2a, resulting in decreased cardiac diastolic function. Here, CREB1 is linked to hydrops fetalis.