Undertreatment with CaMKII antagonist, the regulative effect of NBP on Ca2+-SERCA2a is inhibited, and the myocardial protection of the HF mice model is inhibited, whereas suggesting that NBP treatment activates Ca2+-SERCA2a to promote myocardial calcium and protect the myocardial tissue in HF mice, which is associated with ERS. Here, CAMK2G is linked to amelogenesis imperfecta type 1G.