HIF1A and cancer: The KEGG analysis also revealed (Fig. 5C) significant DEP enrichment in the biosynthesis of secondary metabolites, the lysosome, complement and coagulation cascades, the HIF-1 signalling pathway, glycolysis/gluconeogenesis, cholesterol metabolism, central carbon metabolism in cancer, the PPAR signalling pathway, cytokine-cytokine receptor interaction and other glycan degradation.