SETD2 and injury: The HIF-1 α /HMOX1 pathway has been verified to be necessary in preventing lung damage (He et al., 2018; Han et al., 2020; Shi et al., 2021); and researchers have discovered that activating the HIF-1/HMOX1 signalling pathway can improve LPS-induced acute lung injury by boosting survival rate, reducing inflammation, and reducing oxidative stress.