A functional enrichment analysis of DEPs was performed using GO and KEGG, in which the HIF-1 signalling pathway, biosynthesis of secondary metabolites, central carbon metabolism in cancer, and glycolysis/gluconeogenesis extract had six important DEPs (phosphoglycerate kinase (PGK), hexokinases (HK), lactate dehydrogenase (LDH), phosphoglycerate Mutase (PGAM), phosphofructose kinase(pfkA) and pyruvate dehydrogenase kinase (PDK1) (Table 4). Here, HIF1A is linked to cancer.