The BDNF is a multifunctional neurotrophin with numerous functions in the brain (Jensen et al., 2012; Cagnie et al., 2014), including a driving force behind (maladaptive) neuroplasticity and central sensitization (Nijs et al., 2015), and it is believed to be specifically associated with the occurrence and/or progression of mnemonic symptoms associated with a variety of conditions characterized by cognitive impairment (Napadow et al., 2012). Here, BDNF is linked to Cognitive impairment.