Reportedly, MEG3 can be affected by interaction of the activities of tumor protein 53 (TP53), mouse double minute 2 (human homolog), growth differentiation factor 15, retinoblastoma 1, and other key cell cycle regulators, suggesting that it can be used for cancer diagnosis and prognosis (He et al., 2017), despite the underlying ceRNA mechanism not being understood completely. The gene discussed is TP53; the disease is cancer.