STAT3 and hepatocellular carcinoma: IHC staining results showed that the activated STAT3 (p-STAT3Tyr705) had a high expression level and positively associated with p-ERK1/2Thr202/Tyr204 and p-mTORSer2448 in HCC patient samples with Kras/Erk and mTOR hyperactivation (Figure S11G).