CD8A and neoplasm: Li et al. employed smart organosilica-based nanoplatforms to deliver anti-MCT-4 siRNA (siMCT-4) for blocking tumor intracellular lactate efflux via MCT-4 silencing, resulting in the shift of TAMs phenotype from M2 to M1 and re-activation of CD8+ T cells (Figure 13B, C) 61.