However, in the TME of most solid tumors, TAMs mainly tend to polarize into immunosuppressive M2-like phenotypes thanks to releasing soluble factors such as interleukin-6 (IL-6) and prostaglandin E2 (PGE2) by tumor cells 24-26, which may play a prominent role in promoting the tumor progression by inhibiting antitumor immune response 26. This evidence concerns the gene IL6 and neoplasm.