For example, Shu et al. separately fabricated multifunctional biomimetic NPs or PLGA NPs loading with baicalin and a TLR9 agonist (CpG) for effectively repolarizing M2-like TAMs into tumoricidal M1 phenotype, which further reversed the tumor immunosuppressive state and augmented tumor-specific immune stimulation in anti-melanoma therapy 51, 73. This evidence concerns the gene TLR9 and neoplasm.