VEGFA and neoplasm: Conde et al. employed M2pep-modified AuNPs for targeted delivery of VEGF siRNA (siVEGF) to M2-like TAMs in lung tumor tissues 66, thereby significantly eradicating M2 population from the tumor site by actively silencing VEGF pathway and boosting a T cell-priming immune response that led to durable tumor inhibition (Figure 7A, B).