By analysis of tumor immune environment, it was found that dual-targeting lipid NPs carrying siCD115 remarkably decreased the number of TAMs population accounting for about 52% in tumor tissues, along with a 60% decrease of CD206 (M2-type marker) and a 59% decline of PD-L1 on M2-TAMs (Figure 6D-F). Here, CD274 is linked to neoplasm.