In our previous research (Figure 12B) 96, we reported the immunostimulatory micellar platforms composed of protoporphyrin IX (PpIX)-grafted CS and immunoadjuvant R837 were designed to selectively deliver R837 to TAMs owing to the affinity between CS and CD206, and further activated TAMs through the interaction of R837 with TLR7 receptor on the lysosomal membrane of TAMs, along with abundant production of pro-inflammatory cytokines (TNF-α and IL-6) for eliciting CD8+ T cells-mediated tumor cytotoxicity. This evidence concerns the gene IL6 and neoplasm.