It has been found that the generation of protumoral TAMs is closely associated with Bruton's tyrosine kinase (BTK) overexpressed in TAMs 152, which facilitates the recruitment of bone-marrow-cell infiltration into tumors, subsequently inducing the polarization of M2-like TAMs for fostering tumor growth via triggering immunosuppression 153. The gene discussed is BTK; the disease is neoplasm.