Cocultured with low hnRNPA2B1-expressing myeloma cell lines (Vec MM.1S, or shA2B1 RPMI8226) had comparatively more mature osteoblasts (Figure 3F-G), higher ALP activities (Figure 3H), and higher expression of osteoblast differentiation-associated genes (Figure 3I-J) than those with high levels of hnRNPA2B1. This evidence concerns the gene HNRNPA2B1 and plasma cell myeloma.