Moreover, exosomes isolated from myeloma cells expressing high levels of hnRNPA2B1 (shCtrl RPMI8226 or A2B1 MM.1S) induced more TRAP+ cells formation (Figure 4K) and less mature osteoblasts than those with low levels of hnRNPA2B1 (Figure 4L). This evidence concerns the gene ACP5 and plasma cell myeloma.