We also stained myeloma-bearing mouse femurs for TRAP and Toluidine blue, bone histomorphometric analysis demonstrated a lower bone volume/total volume (BV/TV) (Figure 2D), higher percentage of bone surface eroded by osteoclasts (ES/BS) (Figure 2E), percentage of bone surface covered with osteoclasts (Oc. Here, ACP5 is linked to plasma cell myeloma.