In conclusion, the main findings of this study pointed out that in addition to the well-known pro-inflammatory storm, disturbed integrative networks and increased orders of magnitude along the kinetic timeline of serum soluble mediators (specially CXCL10, IL-6, CCL3 and G-CSF) were associated with distinct disease outcomes in severe COVID-19 patients. Here, CXCL10 is linked to COVID-19.