Single-cell RNA sequencing of the CD39+CD4+ conventional T cell cluster revealed the features associated with a functional antitumor response, intra-tumor cell retention (ITGAE, integrin subunit α1, etc.)and tumor residency [arachidonate 5-lipoxygenase, C-X-C motif chemokine ligand 13 (CXCL13), etc.]. This evidence concerns the gene CD4 and neoplasm.