• Ability to recognize autologous tumor cell lines or human tumor cells with IFN-γ secretion and 4-1BB up-regulation.• Contains a percentage of tumor neoantigen-specific T cells(MART-1、CDKN2Amut peptide HLA-A*1101、OVA、M8 etc.)• Unique TCRβ clonotypes. The gene discussed is MLANA; the disease is neoplasm.