All mentioned cytokines and chemokines (IL-6, IL-8, IL-17A, IL-21, IL-22, GRO-α, MIP-1β, IP10, APRIL) already had been shown to distinguish patients with autoantibody-associated diseases like NMOSD or MOGAD from MS (9, 10, 21–25). This evidence concerns the gene IL6 and myeloid sarcoma.