IFNG and neoplasm: As a result, both MC38-EpCAM and MC38 cells elicited high levels of IFN-γ from splenocytes, in which MC38-EpCAM induced IFN-γ was even higher, indicating that the VV-EpCAM BiTE mediated immune responses in mice was specific to both MC38 tumor and EpCAM (Figure 6D).