The correlation of CNV with mRNA expression of choline metabolism-related genes showed that the correlation of PEMT mRNA expression with CNV was positively correlated in 24 of 33 cancers, especially Kidney Chromophobe (KICH), Esophageal carcinoma (ESCA) and Pheochromocytoma and Paraganglioma (PCPG) (Figure 3B). This evidence concerns the gene PEMT and carcinoma of esophagus.