TLE3 and cancer: We performed a functional enrichment analysis of TLE3, and confirmed the potential effects of the “Wnt signaling pathway” and “Notch signaling pathway.” It has been found that Wnt signaling plays a role in multiple immune cells, including in DCS, NK cells, T cells, B cells, and also macrophages [34], and the Wnt/beta-catenin pathway can regulate the immune response against cancer [35].