We next analyzed the correlations between TLE3 mRNA expression and DNA methyltransferases(DNMT1, DNMT2, DNMT3A, and DNMT3B, Figure 5(c)), and found that TLE3 expression was strongly correlated with DNA methylation in different cancers, particularly in LAML, KICH, LGG, COAD, LIHC, CESC, GBM, KIRP, LUAD, READ, KIRC, UVM, LUSC, ESCA, STAD, THCA, MESO, HNSC, and OV. The gene discussed is DNMT3B; the disease is cancer.