Next, the optimal computational pipeline, i.e. exRNAxeno combined, was applied to total RNA sequencing data from liquid biopsy exRNA from two human xenograft mouse models, i.e. SSP, DSP, TSP and platelets from a breast cancer patient-derived (BRC0004, PDX) and neuroblastoma cell line-derived (SK-N-BE(2C), CDX) xenograft mouse model (Figure 1 and Supplementary Table S1). Here, DSP is linked to neuroblastoma.