BOT are epithelial tumors characterized by variable nuclear atypia.141 As first described by Taylor in 1929, this cancer was first described as a semi-malignant disease142 characterized by a lack of stromal invasion.143 Dobrzyckaet al. analyzed the mutation at codon 12 of theKRAS gene in 78 women with ovarian tumors, including 64 invasive OCs and 14 BOTs, using an RFLP-PCR technique.KRAS codon 12 gene mutations were observed in 6.2% of OC tissue and 14.3% of BOTs.KRAS mutations were found to have a significantly higher frequency in MOC and BOT than serous tumors (p<0.01). The gene discussed is KRAS; the disease is cancer.