Other trends included a negative correlation between tumour necrosis factor alpha and dissociative symptoms, and a positive correlation with interleukin 6, raising questions about an interaction between inflammation and dissociative symptoms;15 however, this process may be mediated by other comorbid disorders, such as depression.141 Further research is needed to better understand the neurobiological basis of dissociative symptoms and disorders. This evidence concerns the gene IL6 and depressive disorder.