The complex causes the dephosphorylation of the stathmin, a major microtubule-destabilizing phosphoprotein.[17] Unphosphorylated stathmin binds to and sequesters tubulin dimers to decrease the microtubule polymer, indirectly leading to microtubule instability.[18] Microtubules regulate cell migration by driving forces as an integral part of the cytoskeleton.[19] It has been reported that CEMIP-mediated destabilization of microtubules is essential to enhance the motility, invasion, and metastasis of tumor cells (Fig. 2).[20,21]. The gene discussed is STMN1; the disease is neoplasm.