CEMIP and neoplasm: Additionally, miR-140-3p expression is negatively associated with CEMIP and is an independent prospective factor for tumor regression for CRC patients.[37] Several studies have demonstrated that down-regulating CEMIP by miR-216a can inhibit the invasion and metastasis of CRC cells, revealing the regulatory role of the miRNA-CEMIP axis in CRC.[38] Individual studies have identified the relationship between the expression of CEMIP and EMT.