NFKB1 and cancer: When aberrantly activated, they increase the expression of proto-oncogenes, anti-apoptotic genes, and cell cycle proteins, promoting cancer metastasis[26,27]. In the NF-κB cascades, NF-κB p50, NF-κB p65, and B-cell lymphoma-3 (BCL-3) are responsible for the carcinogenic potential.[28] Based on the study on the transformed keratinocytes with infinite reproduction ability, both BCL-3 and NF-κB p65 promote CEMIP expression levels.[29]