PLXNA2 and cervical carcinoma: Plexin A2 was identified to bind with the G8 domain of CEMIP-through yeast 2-hybrid experiments.[18,29] Typically, Plexin A2 is responsible for class 3 signaling semaphorin bound to Neurospherins, and sustained activation of class 3 signaling Semaphorin can lead to apoptotic cell death.[30,31] Mechanistic investigations revealed that CEMIP blocks the semaphorin 3A- and plexin A2-dependent apoptotic pathway in cervical cancer cells as they trigger apoptosis only on CEMIP deficiency.