In previous studies, CEMIP has been investigated and reported to be correlated to early detection, cancer cell migration, invasion, and poor prognosis.[44–46] Suh et al proposed that CEMIP is probably valuable for the early detection of pancreatic cancer, while Koga et al showed that it is associated with cancer prognosis.[44] Increased expression of CEMIP may partially promote the aggressive phenotype by increasing the concentration of low molecular weight hyaluronan. This evidence concerns the gene CEMIP and familial pancreatic carcinoma.