Based on clinical records, the serum CEMIP as a diagnostic marker is more accurate than the traditional diagnostic marker CA19-9, suggesting that CEMIP can serve as a novel cancer detection marker.[60] However, much previous research relating to CEMIP and cancers only focused on verifying the potential role of CEMIP in diverse cell lines, and the overexpression of secreted CEMIP was always ignored. Here, CEMIP is linked to cancer.