Since TCF4 protein is a critical transcription factor in the Wnt/β-catenin signaling, CEMIP has been deemed a target gene for this pathway.[33,34] As a core component of this pathway, β-catenin plays a prominent role in regulating multiple genes that participate in cell proliferation, differentiation, and invasion.[34] CEMIP and Wnt are both highly expressed in colorectal adenomas and carcinomas, indicating that CEMIP is a positively regulated protein in this pathway and a presumed marker of transformation in colorectal adenomas.[35]. Here, TCF4 is linked to colorectal adenoma.