CEMIP and colorectal adenoma: Although CEMIP expression in the nucleus has been found in colorectal adenomas, nuclear localization and overexpression of CEMIP may be associated with the presence of β-catenin regardless of the International Union Against Cancer stage.[5] Comparing CEMIP-containing colorectal cancer (CRC) cells and their knockouts suggests that CEMIP is belonged to the Wnt signaling pathway, as changes in 8 Wnt axis genes, including β-catenin expression, share the same regulatory trends.