Results of immunofluorescence analysis demonstrate that deficiency of CEMIP disturbs the re-localization of E-cadherin and zona occludens 1(ZO1) in CaSki cells dependent on EGF-mediated stimulation.[29] Therefore, CEMIP promotes EGF-induced EMT and relates to cell invasion in cervical cancer cells. The gene discussed is EGF; the disease is cervical carcinoma.