In addition, it suggests that semaphorin 3A can drive the apoptotic pathway when the activity of EGFR is inhibited.[29] Moreover, as an EGFR-binding protein, CEMIP can promote phosphorylations of EGFR, sarcoma gene, and mitogen-activated protein kinase 1 (MEK1), indicating that CEMIP links EGFR to downstream kinases. This evidence concerns the gene CEMIP and sarcoma.