Icariside down-regulates HIF-1α and other expressions to promote the proliferation and migration of endothelial progenitor cells, thereby repairing damaged endothelium and promoting.[37,38] Icariside reduces NF-κB p65 (RELA) nuclear translocation by inhibiting or reducing NF-κB signaling pathway,[39] reducing the levels of inflammatory factors such as TNF-α, IL-1β and IL-6, interfering with myocardial ischemia-reperfusion injury and inhibiting the progression of aortic atherosclerosis may be the potential mechanisms of Epimedium to regulate HF. Here, RELA is linked to aortic atherosclerosis.