In summary, MYC, HIF-1α, NF-κB, JUN, TP53 and other genes as downstream regulators of PI3K/Akt signaling pathway, it is hypothesized that Epimedium may regulate the expression of the above genes through PI3K/Akt signaling pathway, and then regulate the downstream signaling pathways of PI3K/Akt pathway, such as HIF-1 signaling pathway and NF-κB signaling pathway, to exert intervention in HF. This evidence concerns the gene NFKB1 and hydrops fetalis.