IFI44L and Zika virus infectious disease: It has been reported that IFI44L is closely associated with tuberculosis,[40] Zika virus infection,[41] hepatitis C[42] and hepatocellular carcinoma.[43] In a study of human retinal pigmented epithelial cells (RPE) in an age-related macular degeneration (AMD) disease model, IFI44L was significantly differentially expressed and may play a role in regulating inflammatory pathways.[44]