CD8A and neoplasm: Statins not only lower cholesterol levels but also improve endothelial function, inhibit vascular inflammation, reduce oxidative stress, and stabilize plaque.[3,17–19] Given such immunomodulatory actions, statins have been used as adjuvants to enhance antigen presentation and to inhibit cholesterol-induced CD8 + T cell exhaustion in tumor microenvironments.[20–22] However, any effect of statins on CD8 + T cell senescence in T2DM patients remains unknown.