In addition, CD19, CD79A, CD79B, and MS4A1 are mainly involved in the regulation of B cell receptor signaling pathway and primary immunodeficiency (see Table, Supplemental Digital Content 2, http://links.lww.com/MD/H937, which shows pathway enrichment of four key genes in LUAD module “pink”). The gene discussed is MS4A1; the disease is inborn error of immunity.