SLIT3 and thyroid cancer: For example, SLIT3 and its regulator MiR-218-2 are simultaneously downregulated in thyroid cancer and synergistically inhibited thyroid cancer cell invasion.[23] In addition, as a 3-binding protein of the ABI family, ABI3BP is down-regulated in esophageal cancer and inhibits the proliferation, activity, migration, and invasion of esophageal cancer cells.