At the same time, the ICU clinicians found her autoimmune related antibodies were abnormal: anti-SSA/Ro52 and anti-SSB antibodies were positive (+++), CD4/CD8 was 1.24, total B cells were 26–91%, IgM antibody was 55.9 Ru/mL, which means she had a combination of autoimmune disease. Here, TRIM21 is linked to autoimmune disease.