It should be emphasized that soluble Fas ligand, granolysin, granzyme B and perforin are markers of SJS/TEN which may lead to serious condition.[46] Treatment includes debridement, keeping the wound moist and clean to reduce fluid loss and prevent infections, using of oral or intravenous fluids and nutritional support, empiric antibiotic therapy to reduce the risk of infection, glucocorticoid and immunoglobulin therapy, and plasma exchange is feasible when necessary.[47–50]. Here, PRF1 is linked to toxic epidermal necrolysis.