It has revealed a tolerable toxicity with most treatment-related adverse events (TRAEs) being grade 1 to 2, consisting of increased aspartate aminotransferase (31%), anemia (22%), increased alanine aminotransferase (21%), constipation (21%) and hypertension (20%), elevated blood creatinane (13%), no at grate 3 to 4. This evidence concerns the gene GPT and anemia (phenotype).