In addition, a large cohort study of 111 malignant astrocytic brain tumors (grade II–IV) with immunohistochemical staining clearly showed that not only high TfR1 expression level but also high ferritin-expressing microglial score are significantly correlated with short survival [46], strongly corroborating the presence of a TAM-mediated iron deposition and recycling network in glioma as an egoistic system by iron-demanding GSCs functionally contributing to glioma progression. This evidence concerns the gene TFRC and central nervous system cancer.