CD163 and central nervous system cancer: Relating to this spatial issue, the phenotype of TAMs in gliomas remains still controversial, although TAMs are often defined as anti-inflammatory M2-Mφs (protumoral) and the ratios of M2-Mφs to monocyte lineages (CD163/CD68 and CD204/CD68) have been commonly used in histopathological diagnosis as important criteria highly associated with malignant grades in human gliomas [20].