IL12B and glioblastoma: This type of Mφs express both an M2 marker CD204 and M1 marker genes Cd86, Tnfa, and Il12b. Particularly, the proinflammatory cytokine IL-12, which plays a central role in the regulation of Th1 antitumoral immune responses, act as a niche factor that directly affects the growth of human GBM patient-derived GSCs.