By taking advantage of fluorescent reporter system using Cx3cr1 and Ccr2 gene promoters, they further clarified that CX3CR1-CCR2high inflammatory monocytes (iMo) from BM, even not CX3CR1highCCR2- circulating ones infiltrate into GBM tissues, where they differentiate into CX3CR1highCCR2low Mφs and CX3CR1highCCR2- microglia-like cells, accounting for most of myeloid cells. Here, CX3CR1 is linked to glioblastoma.