IDH3A and central nervous system cancer: Interestingly, the latest outstanding approach using high-dimensional single-cell profiling (CyTOF) deeply analyzed heterogenous composition of myeloid cells in brain tumor microenvironment (TME) at the single-cell level, and provided the conclusive evidence that TAM composition in gliomas is determined by isocitrate dehydrogenase (IDH) gene mutation; TME of relatively benign IDH1mut gliomas dominantly contain resident microglia and few Mo-derived Mφs (MDMs), while more aggressive IDHwt gliomas are characterized by the elevated infiltration of a large number of MDMs [25].