With regard to interaction with ERBB2, a key molecule in estrogen signaling involved in the upstream molecular network of MACROH2A1 (Supplementary Fig. 8a-c); ERBB2 was reported to interact with MACROH2A1.2, but not with MACROH2A1.1 [46], which might result in MACROH2A1.2-specific function in severe COVID-19 pathogenesis. This evidence concerns the gene ERBB2 and COVID-19.