MACROH2A1 and COVID-19: In our pathway analysis in scRNA-seq of monocytes in PBMCs (Supplementary Fig. 6) and in previous reports [49, 50], type I IFN signaling was suppressed in severe COVID-19 cases, suggesting that MACROH2A1 may be involved in the pathogenesis of refractory COVID-19 through the regulation of typeIIFN production.