Instead, it is approved for Takayasu arthritis (TA) [23], giant cell arthritis (GCA) [24], and adult-onset Still’s disease (AOSD) [25], raising an interesting hypothesis that the role of TNF and IL-6 may differ among IMID based on their distinct roles in the innate and adaptive immune systems or autoantibody production. Here, IL6 is linked to adult-onset Still disease.