In addition, the CXCL8-CXCR2 axis has shown significance, particularly in the liver during sepsis and the onset and progression of various liver diseases, such as alcohol or non-alcohol-related liver disease, hepatitis, cirrhosis, fibrosis, ischemia-reperfusion injury (I/R injury) [10–12]. The gene discussed is CXCR2; the disease is Sepsis.