Twelve dysregulated proteins were commonly found in all models comparing schizophrenia with controls, most of them downregulated in the three models, which included i.e., 14–3-3 protein eta (YWHAH) and spectrin beta chain (SPTBN2); and others, such as poly [ADP-ribose] polymerase 1 (PARP1), were shown upregulated in organoids (Additional file 4: Figure S2). Here, SPTBN2 is linked to schizophrenia.