Additionally, multivariate Cox regression analysis identified DDX1 gene expression (HR = 1.822, 95% CI = 1.139–2.915, P = 0.012) and tumor status (HR = 1.873, 95% CI = 1.172–2.995, P = 0.009) as independent risk factors of total survival for patients with HCC. Here, DDX1 is linked to hepatocellular carcinoma.