CDH1, which encodes a classical cadherin of the cadherin superfamily E-cadherin, was mutated in 20% of GLP patients in our cohort, a frequency comparable to that of non-diffuse GC (6%) and DGC (25%), indicating the significance of CDH1 in pathological diffuse-type gastric cancer, including GLP and DGC. This evidence concerns the gene CDH17 and gastric cancer.