ITGB3 and neoplasm: In addition of that, a whole bunch of IGTA/IGTB Integrins superfamily members were found up-regulated in GLP (Fig. 3F), which are also upstream molecules of PI3K-AKT pathway and ITGB3, which encoded integrin beta chain beta-3, was considered a cancer-associated fibroblasts (CAFs)-related gene and induced breast tumor invasiveness through crosstalk between CAFs and tumor cells[52].