Since we found the concomitant changes in SCFA, GPR41, GPR43 and IGF1 in SCD mice after receiving FMT from Ctrl feces, it is possible that decrease of SCFAs leads to less GPR41/43 expression in bone, and subsequently reduce IGF1 production are responsible for low bone mass in SCD mice. The gene discussed is FFAR2; the disease is Schnyder corneal dystrophy.