As shown in Fig. 7D–F, we found significantly decreased IGF1 mRNA and protein level in flushed tibia and serum in SCD mice fed SCD feces compared with Ctrl mice fed Ctrl feces, whereas transplantation of Ctrl feces to SCD recipient restored IGF1 level in bone to Ctrl mice levels. The gene discussed is IGF1; the disease is Schnyder corneal dystrophy.