PHLDA1 and colitis: We observed that TDAG51 expression was elevated in the distal anorectal region of colon tissues of DSS-induced colitis model mice compared to those of control mice, whereas the basal level and DSS-induced induction of TDAG51 expression were not detected in the distal anorectal region of colon tissues in TDAG51−/− mice (Fig. 1B).