Moreover, many other factors which are directly induced by Wnt/β-catenin signaling such as TCF7L2, GLP-1, PPARγ, FGF19, and FGF21 are also attributed to the anti-obesity accompanying suppression of inflammation28–30, hepatic steatosis30,31, and activation of browning of WAT32, resulting in improvement of the multiple metabolic parameters. The gene discussed is FGF21; the disease is obesity due to melanocortin 4 receptor deficiency.