We observed higher anti-ADAMTSL5 IgG in PsA serum (575 μg/mL (IQR 321–1523)), as compared to HC serum (205 μg/mL (IQR 28–833), P = 0.004), psoriasis serum (319 μg/mL (IQR 103–645), P = 0.012) and PsA synovial fluid (138 μg/mL (IQR 77–348), P =  < 0.0001)(Fig. 6A, Supplemental Figure S6A). This evidence concerns the gene ADAMTSL5 and psoriasis.