MTOR and colorectal carcinoma: ERS signaling pathways including EIF2 (p = 6.59E−07, z-score: − 3.30), integrin-linked kinase (ILK; p = 1.23E−05, z-score: − 1.62), and mTOR (p = 0.042; z-score: 0) were among the most significantly affected canonical pathways in Native Hawaiian CRC-S patients (Fig. 3).