TGFB3 and oral lichen planus: Also, individual investigations related to the pathogenic Th17 molecular signature in OLP showed high levels for several genes involved in tumor progression such as TGFB3, IL1B, HIF1A, LTA,and LTB. Wang and colleagues showed that HIF1A was up-regulated in OLP and OSCC samples, contributing to changes in the expression of genes involved in adaptation to hypoxia and tumor progression32.