AR and posterior cortical atrophy: Having established an association of AR enhancer heterogeneity in PCa with biological consequences on enhancer activity, we next investigated the impact of 764 risk single nucleotide polymorphisms (rSNPs)26–28 and single nucleotide variation (SNV) reported previously in primary PCa (n = 278,209)10 and in metastatic PCa (mPCa, n = 1,048,576)11 on primary ranked ARBS as SNVs accumulate during PCa progression.