Notably, heterogeneous case met-ARBS regulate hallmarks of cancer pathways involved in cholesterol synthesis43, mTORC1 signaling44, androgen response, and WNT beta-catenin signaling44, whereas the P53 pathway, which is often inactivated in mPCa10,45, was activated by heterogeneous control met-ARBS. This evidence concerns the gene CTNNB1 and cancer.