Our results examined that the undocumented anti-senescent role of renal tubular FFAR4 is regulated through the aging-associated SirT3 expression via Gq subunit-mediated CaMKKβ/AMPK signaling in cisplatin-treated AKI mice and TCMK-1 cells, this may present a novel pathogenic mechanism of AKI. The gene discussed is CAMKK2; the disease is acute kidney injury.