To investigate the regulation of resident macrophages during NICM, we first assessed the number of macrophages in the left ventricle (LV) tissue of B6J mice following Ang-II infusion (500 ng/kg/min), a well-established non-ischemic model of arterial hypertension, cardiac hypertrophy, and fibrosis40. The gene discussed is AGT; the disease is cardiac hypertrophy.