Nevertheless, the interaction between CHES1 with transcriptional activator p300 in breast cancer cells might partially explain its dual function in transcriptional regulation (Figs. 4D, E and S5F), Yu et al. also found that CHES1 served as a transcriptional activator to upregulate Dpp expression in Drosophila testis [42]. The gene discussed is FOXN3; the disease is breast cancer.