ACE and acute respiratory distress syndrome: In addition to occupying ACE2 on the cell surface, intracellular replication of SARS‐CoV‐2 causes a decrease in ACE2 expression, which eventually leads to ACE2 catabolism to ACE, and when ACE2/ACE signalling is blocked, then severe reactions may occur in the body, such as vasoconstriction, hypokalaemia, acute respiratory distress syndrome, and acute renal failure (Beyerstedt et al., 2021; Bourgonje et al., 2020).