ACE2 and infection: (1) When SARS‐CoV‐2 enters the cell microenvironment, EVs that carry angiotensin‐converting enzyme 2 (ACE2) as nanodecoys may prevent or assist virus colonization and entry (Berry et al., 2022; Cocozza et al., 2020; El‐Shennawy et al., 2022), (2) When infection occurs, EVs obtained by in vitro cultivation of immune cells, mesenchymal stem cells, and other cells may be used to guard against intracellular replication, spread of the virus, and act as cytokine decoys (Chutipongtanate et al., 2022; Elashiry et al., 2021; Wang et al., 2022a).