ALDH1A1 is highly expressed in the kidney and liver, and mutations of this enzyme have been associated with a number of human diseases, including cancer, Parkinson’s disease, and obesity (Ziouzenkova et al, 2007; Wey et al, 2012; Tomita et al, 2016). This evidence concerns the gene ALDH1A1 and obesity due to melanocortin 4 receptor deficiency.